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desvenlafaxine will improve the degree or effect of codeine by impacting hepatic enzyme CYP2D6 metabolism. Use Warning/Keep track of. Desvenlafaxine inhibits CYP2D6; with larger desvenlafaxine doses (ie, 400 mg) lessen the CYP2D6 substrate dose by approximately 50%; no dosage adjustment desired with desvenlafaxine doses seven consecutive times prom